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You can change the I2C address through our standard APIs:
C: zkSetI2CAddr
Python: set_i2c_address -
The I2C communication between the Zymkey and the Host is encrypted, but will not interfere with other devices on the same bus (assuming there is no address conflict).
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Are you trying to a) put multiple zymkeys on the same host, or b) put one zymkey with other I2C devices on the same host ?